Laboratory studies
Experimental laboratory studies are vital to the translational research pathway. Many scientists have limited access to statistical support, and the partnership required between statisticians and scientists to undertake high quality research is often lacking.
As a group we want to build communication between scientists and statisticians. We worked with laboratory scientists to produce the RIPOSTE framework, which aims to facilitate discussion between the two disciplines at the design of a study. We are planning to produce further publications which focus on specific methodological areas, such as this one on unit of analysis issues.
The group organises meetings and webinars, as well as breakout sessions at the annual conference. Previous topics have included:
- Handling censored values in analysis
- Biomarker development
- Variation and repeatability of test results, and
- Improving the design and analysis of studies using qPCR
The term ‘laboratory studies’ is imprecise and covers a disparate range of studies. We aim to refine what we mean by the term ‘laboratory studies’.
The laboratory studies working group has its own JISCMAIL mailing list.
If you would like to join a working group committee or wish to find out more, please email the NIHR Statistics Group.
Group leaders
-
Alice Sitch
University of Birmingham
-
Christina Easter
University of Birmingham
Committee members
-
Ben Towler
Brighton & Sussex Medical School
-
Chris Jones
Brighton & Sussex Medical School
-
George Bouliotis
Warwick University
-
Jérémie Nsengimana
Newcastle University
-
James Hawley
Manchester University NHS Foundation Trust
-
Michelle Wilson
University of Leeds
-
Dawn Teare
Newcastle University
Active group members
-
Amin Vahdati
University of Manchester
-
Aimee Jackson
University of Birmingham
Former leaders and members
- Dawn Teare
- Liz Hensor
- Victoria Cornelius
- Nick Masca
Publications
-
Science Forum: Unit of analysis issues in laboratory-based research
eLife 2018;7:e32486
-
RIPOSTE: a framework for improving the design and analysis of laboratory-based research
eLIFE; 2015; 4:e05519
Past events
-
Workshop: Basics of Linear Regression and Agreement Statistics
22 March 2024
-
Basic concepts in statistics (choosing tests, p-values and displaying data)
4 March 2022
-
Accessing and analysing high-throughput genomic data from public repositories
25 February 2022
-
Design and analysis of quantitative PCR experiments for laboratory scientists and statisticians
3 September 2021
-
Novel trial designs in precision medicine
3 May 2019
-
Reproducible Research and Registered Reports
20 March 2017
-
Royal Statistical Society and NIHR Statistics Group meeting in Data Monitoring Committees and Simple Adaptive/Efficient Designs
19 January 2016
-
RIPOSTE Statistical Seminar
5 November 2014
-
RIPOSTE Statistical Seminar
21 October 2014
-
RIPOSTE Consortium
10 February 2014
-
Influencing the design and analysis of laboratory studies
12 April 2013